Assay Detail
Binding
CHEMBL768965
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Inhibitory activity against prostaglandin G/H synthase 2 (COX-2).
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Diarylspiro[2.4]heptenes as orally active, highly selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 8.31 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313387 | — | — | 1 | 9.00 |
| CHEMBL327384 | — | — | 1 | 9.00 |
| CHEMBL330314 | — | — | 1 | 9.00 |
| CHEMBL432945 | — | — | 1 | 9.00 |
| CHEMBL88717 | — | — | 1 | 9.00 |
| CHEMBL92102 | — | — | 1 | 8.82 |
| CHEMBL312822 | — | — | 1 | 8.82 |
| CHEMBL315585 | — | — | 1 | 8.70 |
| CHEMBL329999 | — | — | 1 | 8.70 |
| CHEMBL313313 | — | — | 1 | 8.70 |
| CHEMBL88532 | — | — | 1 | 8.70 |
| CHEMBL88549 | — | — | 1 | 8.60 |
| CHEMBL89429 | — | — | 1 | 8.59 |
| CHEMBL274893 | SC-57666 | — | 1 | 8.59 |
| CHEMBL17184 | — | — | 1 | 8.52 |
| CHEMBL558340 | — | — | 1 | 8.52 |
| CHEMBL314225 | — | — | 1 | 8.52 |
| CHEMBL92107 | — | — | 1 | 8.48 |
| CHEMBL90447 | — | — | 1 | 8.40 |
| CHEMBL88493 | — | — | 1 | 8.40 |
| CHEMBL89089 | — | — | 1 | 8.30 |
| CHEMBL315520 | — | — | 1 | 8.22 |
| CHEMBL88286 | — | — | 1 | 8.15 |
| CHEMBL92154 | — | — | 1 | 8.10 |
| CHEMBL88550 | — | — | 1 | 8.00 |
| CHEMBL86363 | — | — | 1 | 7.89 |
| CHEMBL88899 | — | — | 1 | 7.77 |
| CHEMBL314297 | — | — | 1 | 7.66 |
| CHEMBL89625 | — | — | 1 | 7.57 |
| CHEMBL91258 | — | — | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313387 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL88717 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL432945 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL330314 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL327384 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL92102 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL312822 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL315585 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL329999 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL313313 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL88532 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL88549 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL89429 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL274893 | SC-57666 | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL314225 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL17184 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL558340 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL92107 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL88493 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL90447 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL89089 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL315520 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL88286 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL92154 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL88550 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL86363 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL88899 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL314297 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL89625 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL91258 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL327900 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL88649 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL89263 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL328146 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL89578 | — | IC50 | = | 15000.0 | nM | - |