Assay Detail
Functional
CHEMBL769008
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alpha
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.97 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75133 | IRX-4204 | 2.0 | 1 | 9.70 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 8.82 |
| CHEMBL308377 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75133 | IRX-4204 | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL705 | ALITRETINOIN | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL308377 | — | EC50 | = | 4.0 | nM | 8.40 |