Assay Detail
Binding
CHEMBL769037
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Inhibition of Protein kinase A
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
cAMP-dependent protein kinase (PKA) (CHEMBL2094138) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.79 | 4.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124620 | — | — | 1 | 4.79 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | — | 1 | - |
| CHEMBL62253 | — | — | 1 | - |
| CHEMBL266487 | RO-316233 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124620 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | IC50 | > | 2000.0 | nM | - |
| CHEMBL62253 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL266487 | RO-316233 | IC50 | > | 2000.0 | nM | - |