Assay Detail
Binding
CHEMBL769053
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Inhibition of HIV-1 protease
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.81 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319092 | — | — | 1 | 10.52 |
| CHEMBL296115 | — | — | 1 | 9.52 |
| CHEMBL101560 | — | — | 1 | 9.48 |
| CHEMBL98885 | — | — | 1 | 8.91 |
| CHEMBL99600 | — | — | 1 | 7.31 |
| CHEMBL18389 | — | — | 1 | 6.80 |
| CHEMBL321571 | — | — | 1 | 6.51 |
| CHEMBL330615 | — | — | 1 | 6.50 |
| CHEMBL327277 | — | — | 1 | 6.41 |
| CHEMBL99213 | — | — | 1 | 6.16 |
| CHEMBL319408 | — | — | 1 | - |
| CHEMBL82338 | — | — | 1 | - |
| CHEMBL319792 | — | — | 1 | - |
| CHEMBL430469 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319092 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL296115 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL101560 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL98885 | — | IC50 | = | 1.22 | nM | 8.91 |
| CHEMBL99600 | — | IC50 | = | 48.9 | nM | 7.31 |
| CHEMBL18389 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL321571 | — | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL330615 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL327277 | — | IC50 | = | 392.0 | nM | 6.41 |
| CHEMBL99213 | — | IC50 | = | 694.0 | nM | 6.16 |
| CHEMBL319408 | — | IC50 | < | 0.03 | nM | - |
| CHEMBL82338 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL319792 | — | IC50 | < | 0.03 | nM | - |
| CHEMBL430469 | — | IC50 | < | 0.03 | nM | - |