Assay Detail
Binding
CHEMBL769060
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Binding affinity for HIV-1 protease enzyme was measured by using fluorescent peptide substrate
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Nonpeptide cyclic cyanoguanidines as HIV-1 protease inhibitors: synthesis, structure-activity relationships, and X-ray crystal structure studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 48 | 8.12 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35860 | — | — | 1 | 9.92 |
| CHEMBL284136 | — | — | 1 | 9.92 |
| CHEMBL285417 | — | — | 1 | 9.85 |
| CHEMBL223824 | MOZENAVIR | 2.0 | 1 | 9.55 |
| CHEMBL33647 | — | — | 1 | 9.51 |
| CHEMBL21145 | DMP-323 | — | 1 | 9.47 |
| CHEMBL287112 | — | — | 1 | 9.14 |
| CHEMBL287220 | — | — | 1 | 8.96 |
| CHEMBL287355 | — | — | 1 | 8.89 |
| CHEMBL284472 | — | — | 1 | 8.85 |
| CHEMBL286791 | — | — | 1 | 8.82 |
| CHEMBL286393 | — | — | 1 | 8.80 |
| CHEMBL291234 | — | — | 1 | 8.77 |
| CHEMBL36129 | — | — | 1 | 8.70 |
| CHEMBL431306 | — | — | 1 | 8.68 |
| CHEMBL285154 | — | — | 1 | 8.59 |
| CHEMBL285180 | — | — | 1 | 8.57 |
| CHEMBL415040 | — | — | 1 | 8.55 |
| CHEMBL290576 | — | — | 1 | 8.52 |
| CHEMBL286531 | — | — | 1 | 8.52 |
| CHEMBL289234 | — | — | 1 | 8.42 |
| CHEMBL287274 | — | — | 1 | 8.37 |
| CHEMBL284314 | — | — | 1 | 8.28 |
| CHEMBL286456 | — | — | 1 | 8.24 |
| CHEMBL287049 | — | — | 1 | 8.13 |
| CHEMBL32733 | — | — | 1 | 8.10 |
| CHEMBL286777 | — | — | 1 | 7.96 |
| CHEMBL284491 | — | — | 1 | 7.92 |
| CHEMBL35405 | — | — | 1 | 7.85 |
| CHEMBL32143 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35860 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL284136 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL285417 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL223824 | MOZENAVIR | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL33647 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL21145 | DMP-323 | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL287112 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL287220 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL287355 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL284472 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL286791 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL286393 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL291234 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL36129 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL431306 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL285154 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL285180 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL415040 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL290576 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL286531 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL289234 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL287274 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL284314 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL286456 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL287049 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL32733 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL286777 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL284491 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL35405 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL32143 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL36118 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL33369 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL285903 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL285498 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL34656 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL405765 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL32828 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL286869 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL35980 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL35901 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL286668 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL290336 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL33829 | — | Ki | = | 267.0 | nM | 6.57 |
| CHEMBL35301 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL286361 | — | Ki | = | 542.0 | nM | 6.27 |
| CHEMBL32884 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL284087 | — | Ki | = | 1370.0 | nM | 5.86 |
| CHEMBL289024 | — | Ki | > | 12500.0 | nM | - |