Assay Detail
Binding
CHEMBL769062
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Binding affinity for HIV-1 protease
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
HIV protease inhibitory bis-benzamide cyclic ureas: a quantitative structure-activity relationship analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 10.03 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81383 | — | — | 1 | 11.00 |
| CHEMBL85653 | — | — | 1 | 11.00 |
| CHEMBL405187 | — | — | 1 | 11.00 |
| CHEMBL316147 | — | — | 1 | 10.74 |
| CHEMBL315929 | — | — | 1 | 10.70 |
| CHEMBL408834 | — | — | 1 | 10.70 |
| CHEMBL262642 | — | — | 1 | 10.70 |
| CHEMBL262378 | — | — | 1 | 10.70 |
| CHEMBL85990 | — | — | 1 | 10.52 |
| CHEMBL431027 | — | — | 1 | 10.40 |
| CHEMBL82606 | — | — | 1 | 10.22 |
| CHEMBL311499 | — | — | 1 | 10.22 |
| CHEMBL86454 | — | — | 1 | 10.20 |
| CHEMBL313734 | — | — | 1 | 10.10 |
| CHEMBL315825 | — | — | 1 | 10.05 |
| CHEMBL314058 | — | — | 1 | 9.92 |
| CHEMBL431017 | — | — | 1 | 9.82 |
| CHEMBL275024 | — | — | 1 | 9.68 |
| CHEMBL81396 | — | — | 1 | 9.68 |
| CHEMBL421730 | — | — | 1 | 9.62 |
| CHEMBL85585 | — | — | 1 | 9.59 |
| CHEMBL314008 | — | — | 1 | 9.55 |
| CHEMBL433404 | — | — | 1 | 9.54 |
| CHEMBL137526 | — | — | 1 | 9.43 |
| CHEMBL405189 | — | — | 1 | 9.39 |
| CHEMBL86913 | — | — | 1 | 9.37 |
| CHEMBL86441 | — | — | 1 | 9.24 |
| CHEMBL336452 | — | — | 1 | 9.15 |
| CHEMBL313516 | — | — | 1 | 8.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81383 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL85653 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL405187 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL316147 | — | Ki | = | 0.018 | nM | 10.74 |
| CHEMBL315929 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL408834 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL262642 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL262378 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL85990 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL431027 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL82606 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL311499 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL86454 | — | Ki | = | 0.063 | nM | 10.20 |
| CHEMBL313734 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL315825 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL314058 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL431017 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL275024 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL81396 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL421730 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL85585 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL314008 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL433404 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL137526 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL405189 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL86913 | — | Ki | = | 0.424 | nM | 9.37 |
| CHEMBL86441 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL336452 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL313516 | — | Ki | = | 2.6 | nM | 8.59 |