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Assay Detail

CHEMBL769064

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Binding
Inhibitory activity against HIV-1 protease
ChEMBL ↗
43
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 1
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Human immunodeficiency virus type 1 protease (CHEMBL243) ↗
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

HIV protease inhibitory bis-benzamide cyclic ureas: a quantitative structure-activity relationship analysis.
Wilkerson WW, Akamike E, Cheatham WW, Hollis AY, Collins RD, DeLucca I, Lam PY, Ru Y.
J Med Chem (1996) 39 : 4299 -4312
PubMed 8863807 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 43 10.01 10.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL85653 — — 1 10.96
CHEMBL405187 — — 1 10.92
CHEMBL291677 — — 1 10.85
CHEMBL313959 — — 1 10.85
CHEMBL408834 — — 1 10.80
CHEMBL316147 — — 1 10.74
CHEMBL262642 — — 1 10.74
CHEMBL315929 — — 1 10.70
CHEMBL262378 — — 1 10.70
CHEMBL11266 — — 1 10.62
CHEMBL86398 — — 1 10.60
CHEMBL57375 — — 1 10.57
CHEMBL85990 — — 1 10.57
CHEMBL431027 — — 1 10.46
CHEMBL311499 — — 1 10.41
CHEMBL81383 — — 1 10.37
CHEMBL313734 — — 1 10.35
CHEMBL86454 — — 1 10.20
CHEMBL89132 — — 1 10.19
CHEMBL82606 — — 2 10.18
CHEMBL315825 — — 1 10.07
CHEMBL280046 — — 1 9.96
CHEMBL314058 — — 1 9.94
CHEMBL431017 — — 1 9.82
CHEMBL116 AMPRENAVIR 4.0 1 9.77
CHEMBL87835 — — 1 9.74
CHEMBL275024 — — 1 9.68
CHEMBL81396 — — 1 9.68
CHEMBL421730 — — 1 9.61
CHEMBL114 SAQUINAVIR 4.0 1 9.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL85653 — Ki = 0.011 nM 10.96
CHEMBL405187 — Ki = 0.012 nM 10.92
CHEMBL313959 — Ki = 0.014 nM 10.85
CHEMBL291677 — Ki = 0.014 nM 10.85
CHEMBL408834 — Ki = 0.016 nM 10.80
CHEMBL316147 — Ki = 0.018 nM 10.74
CHEMBL262642 — Ki = 0.018 nM 10.74
CHEMBL315929 — Ki = 0.02 nM 10.70
CHEMBL262378 — Ki = 0.02 nM 10.70
CHEMBL11266 — Ki = 0.024 nM 10.62
CHEMBL86398 — Ki = 0.025 nM 10.60
CHEMBL85990 — Ki = 0.027 nM 10.57
CHEMBL57375 — Ki = 0.027 nM 10.57
CHEMBL431027 — Ki = 0.035 nM 10.46
CHEMBL311499 — Ki = 0.039 nM 10.41
CHEMBL81383 — Ki = 0.043 nM 10.37
CHEMBL313734 — Ki = 0.045 nM 10.35
CHEMBL86454 — Ki = 0.063 nM 10.20
CHEMBL89132 — Ki = 0.064 nM 10.19
CHEMBL82606 — Ki = 0.066 nM 10.18
CHEMBL315825 — Ki = 0.085 nM 10.07
CHEMBL280046 — Ki = 0.11 nM 9.96
CHEMBL314058 — Ki = 0.115 nM 9.94
CHEMBL431017 — Ki = 0.152 nM 9.82
CHEMBL116 AMPRENAVIR Ki = 0.17 nM 9.77
CHEMBL87835 — Ki = 0.18 nM 9.74
CHEMBL275024 — Ki = 0.21 nM 9.68
CHEMBL81396 — Ki = 0.21 nM 9.68
CHEMBL421730 — Ki = 0.245 nM 9.61
CHEMBL114 SAQUINAVIR Ki = 0.25 nM 9.60
CHEMBL85585 — Ki = 0.26 nM 9.59
CHEMBL433404 — Ki = 0.29 nM 9.54
CHEMBL21145 DMP-323 Ki = 0.32 nM 9.49
CHEMBL314008 — Ki = 0.359 nM 9.45
CHEMBL163 RITONAVIR Ki = 0.37 nM 9.43
CHEMBL5483011 INDINAVIR Ki = 0.37 nM 9.43
CHEMBL405189 — Ki = 0.41 nM 9.39
CHEMBL137526 — Ki = 0.43 nM 9.37
CHEMBL86913 — Ki = 0.424 nM 9.37
CHEMBL86441 — Ki = 0.579 nM 9.24
CHEMBL336452 — Ki = 0.741 nM 9.13
CHEMBL82606 — Ki = 1.9 nM 8.72
CHEMBL313516 — Ki = 2.4 nM 8.62