Assay Detail
Binding
CHEMBL769088
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Inhibition of Trypanosoma brucei protein farnesyltransferase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei brucei |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.26 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54044 | — | — | 1 | 8.77 |
| CHEMBL431828 | — | — | 1 | 8.74 |
| CHEMBL336915 | — | — | 1 | 8.23 |
| CHEMBL138192 | — | — | 1 | 8.18 |
| CHEMBL135561 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54044 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL431828 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL336915 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL138192 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL135561 | — | IC50 | = | 40.0 | nM | 7.40 |