Assay Detail
Binding
CHEMBL769112
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Inhibition of Protein kinase C epsilon
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.62 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.75 |
| CHEMBL91829 | RUBOXISTAURIN | 3.0 | 1 | 6.22 |
| CHEMBL311543 | — | — | 1 | 5.96 |
| CHEMBL419866 | — | — | 1 | 5.42 |
| CHEMBL328229 | — | — | 1 | 4.24 |
| CHEMBL292495 | — | — | 1 | 4.10 |
| CHEMBL91959 | — | — | 1 | - |
| CHEMBL315357 | — | — | 1 | - |
| CHEMBL315389 | — | — | 1 | - |
| CHEMBL316239 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL91829 | RUBOXISTAURIN | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL311543 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL419866 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL328229 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL292495 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL91959 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL315357 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL315389 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL316239 | — | IC50 | > | 5000.0 | nM | - |