Assay Detail

CHEMBL769133

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Binding

Inhibition of PKG (protein kinase G)

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum.

Gompel M, Leost M, De Kier Joffe EB, Puricelli L, Franco LH, Palermo J, Meijer L.
Bioorg Med Chem Lett (2004) 14 : 1703 -1704
PubMed 15026054 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.22	6.22

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL296682	MERIDIANIN E	—	1	6.22
CHEMBL14762	SELICICLIB	2.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL296682	MERIDIANIN E	IC50	=	600.0	nM	6.22
CHEMBL14762	SELICICLIB	IC50	>	1000000.0	nM	-