Assay Detail
Binding
CHEMBL769134
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Inhibition of PKG (protein kinase G)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.18 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44541 | MERIDIANIN C | — | 1 | 6.40 |
| CHEMBL296271 | — | — | 1 | 6.22 |
| CHEMBL46440 | MERIDIANIN D | — | 1 | 6.10 |
| CHEMBL44545 | MERIDIANIN B | — | 1 | 6.00 |
| CHEMBL50226 | — | — | 1 | - |
| CHEMBL48081 | — | — | 1 | - |
| CHEMBL48082 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44541 | MERIDIANIN C | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL296271 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL46440 | MERIDIANIN D | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL44545 | MERIDIANIN B | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL50226 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL48081 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL48082 | — | IC50 | = | 400000.0 | nM | - |