Assay Detail
Binding
CHEMBL769139
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit autophosphorylation of cytoplasmic domain of human epidermal growth factor receptor-2
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Receptor tyrosine-protein kinase erbB-2 (CHEMBL1824) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor-2 (HER-2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.50 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116853 | — | — | 1 | 6.75 |
| CHEMBL114593 | — | — | 1 | 6.52 |
| CHEMBL113900 | — | — | 1 | 6.50 |
| CHEMBL115187 | — | — | 1 | 6.43 |
| CHEMBL414631 | — | — | 1 | 6.42 |
| CHEMBL326280 | — | — | 1 | 6.42 |
| CHEMBL115440 | — | — | 1 | 6.35 |
| CHEMBL327023 | — | — | 1 | 5.98 |
| CHEMBL117326 | — | — | 1 | 5.92 |
| CHEMBL607707 | PELITINIB | 2.0 | 1 | 5.91 |
| CHEMBL157128 | — | — | 1 | 5.91 |
| CHEMBL281300 | — | — | 1 | 5.79 |
| CHEMBL323630 | — | — | 1 | 5.71 |
| CHEMBL116525 | — | — | 1 | 5.67 |
| CHEMBL114728 | — | — | 1 | 5.53 |
| CHEMBL283682 | — | — | 1 | 5.41 |
| CHEMBL30973 | — | — | 1 | 5.38 |
| CHEMBL421047 | — | — | 1 | 5.38 |
| CHEMBL114392 | — | — | 1 | 5.36 |
| CHEMBL326811 | — | — | 1 | 5.35 |
| CHEMBL114490 | — | — | 1 | 5.35 |
| CHEMBL324718 | — | — | 1 | 5.33 |
| CHEMBL263788 | — | — | 1 | 5.25 |
| CHEMBL424252 | — | — | 1 | 5.11 |
| CHEMBL118000 | — | — | 1 | 5.06 |
| CHEMBL116857 | — | — | 1 | 5.03 |
| CHEMBL325156 | — | — | 1 | 5.02 |
| CHEMBL113901 | — | — | 1 | 4.93 |
| CHEMBL113902 | — | — | 1 | 4.67 |
| CHEMBL113985 | — | — | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116853 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL114593 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL113900 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL115187 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL414631 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL326280 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL115440 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL327023 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL117326 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL607707 | PELITINIB | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL157128 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL281300 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL323630 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL116525 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL114728 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL283682 | — | IC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL421047 | — | IC50 | = | 4130.0 | nM | 5.38 |
| CHEMBL30973 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL114392 | — | IC50 | = | 4390.0 | nM | 5.36 |
| CHEMBL326811 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL114490 | — | IC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL324718 | — | IC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL263788 | — | IC50 | = | 5660.0 | nM | 5.25 |
| CHEMBL424252 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL118000 | — | IC50 | = | 8740.0 | nM | 5.06 |
| CHEMBL116857 | — | IC50 | = | 9350.0 | nM | 5.03 |
| CHEMBL325156 | — | IC50 | = | 9580.0 | nM | 5.02 |
| CHEMBL113901 | — | IC50 | = | 11820.0 | nM | 4.93 |
| CHEMBL113902 | — | IC50 | = | 21510.0 | nM | 4.67 |
| CHEMBL113985 | — | IC50 | = | 23590.0 | nM | 4.63 |
| CHEMBL113996 | — | IC50 | = | 31430.0 | nM | 4.50 |
| CHEMBL114073 | — | IC50 | = | 33950.0 | nM | 4.47 |
| CHEMBL116012 | — | IC50 | = | 33950.0 | nM | 4.47 |
| CHEMBL332497 | — | IC50 | = | 34130.0 | nM | 4.47 |