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Assay Detail

CHEMBL769205

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Binding
Compound was evaluated for inhibitory effect against protein phosphatase I (PP-I)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Protein phosphatase 1A (CHEMBL2437)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Michael adducts of ascorbic acid as inhibitors of protein phosphatase 2A and inducers of apoptosis.
Fathi AR, Krautheim A, Kaap S, Eger K, Steinfelder HJ.
Bioorg Med Chem Lett (2000) 10 : 1605 -1608
PubMed 10915062 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.24 5.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL40779 1 5.52
CHEMBL416976 1 4.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL40779 IC50 = 3000.0 nM 5.52
CHEMBL416976 IC50 = 11000.0 nM 4.96