Assay Detail
Binding
CHEMBL769255
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Inhibitory activity against recombinant HIV-1 Protease
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-based, C2 symmetric inhibitors of HIV protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.04 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83462 | — | — | 1 | 9.66 |
| CHEMBL430891 | — | — | 1 | 8.52 |
| CHEMBL90174 | — | — | 1 | 8.31 |
| CHEMBL88255 | — | — | 1 | 8.00 |
| CHEMBL275554 | — | — | 1 | 7.92 |
| CHEMBL2311105 | — | — | 1 | 7.92 |
| CHEMBL9618 | — | — | 1 | 7.40 |
| CHEMBL9726 | — | — | 1 | 6.55 |
| CHEMBL9735 | — | — | 1 | - |
| CHEMBL88254 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83462 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL430891 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL90174 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL88255 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL275554 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2311105 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL9618 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL9726 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL9735 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL88254 | — | IC50 | > | 100.0 | nM | - |