Assay Detail
Binding
CHEMBL769298
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Inhibitory activity against Human Cytomegalovirus (HCMV) polymerase
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human betaherpesvirus 5 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
DNA polymerase catalytic subunit (CHEMBL4009) ↗| Type | SINGLE PROTEIN |
| Organism | Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human Blymphotropic virus) |
Publication
Naphthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.09 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29711 | APHIDICOLIN | — | 1 | 6.40 |
| CHEMBL66078 | — | — | 1 | 6.12 |
| CHEMBL62295 | — | — | 1 | 6.09 |
| CHEMBL62784 | — | — | 1 | 5.62 |
| CHEMBL65757 | — | — | 1 | 5.62 |
| CHEMBL66188 | — | — | 1 | 5.54 |
| CHEMBL292775 | — | — | 1 | 5.48 |
| CHEMBL66652 | — | — | 1 | 5.42 |
| CHEMBL418669 | — | — | 1 | 5.40 |
| CHEMBL63201 | — | — | 1 | 5.22 |
| CHEMBL65137 | — | — | 1 | 5.19 |
| CHEMBL61847 | — | — | 1 | 5.10 |
| CHEMBL442562 | — | — | 1 | 4.97 |
| CHEMBL65973 | — | — | 1 | 4.92 |
| CHEMBL65374 | — | — | 1 | 4.92 |
| CHEMBL62846 | — | — | 1 | 4.89 |
| CHEMBL292344 | — | — | 1 | 4.84 |
| CHEMBL65742 | — | — | 1 | 4.72 |
| CHEMBL63275 | — | — | 1 | 4.66 |
| CHEMBL294267 | — | — | 1 | 4.66 |
| CHEMBL305579 | — | — | 1 | 4.43 |
| CHEMBL293187 | — | — | 1 | 4.28 |
| CHEMBL63883 | — | — | 1 | 4.25 |
| CHEMBL65164 | — | — | 1 | 4.23 |
| CHEMBL65653 | — | — | 1 | 4.16 |
| CHEMBL63723 | — | — | 1 | - |
| CHEMBL63411 | — | — | 1 | - |
| CHEMBL63149 | — | — | 1 | - |
| CHEMBL63264 | — | — | 1 | - |
| CHEMBL63731 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29711 | APHIDICOLIN | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL66078 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL62295 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL62784 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL65757 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL66188 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL292775 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL66652 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL418669 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL63201 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL65137 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL61847 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL442562 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL65973 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL65374 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL62846 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL292344 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL65742 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL63275 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL294267 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL305579 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL293187 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL63883 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL65164 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL65653 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL304651 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL62396 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL63313 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL63234 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL65408 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL65652 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL63731 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL63264 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL63149 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL63411 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL63723 | — | IC50 | > | 100000.0 | nM | - |