Assay Detail
Functional
CHEMBL769300
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for 50% inhibition of HBV polymerases (Hepatitis B virus)
9
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.95 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483492 | — | — | 2 | 7.52 |
| CHEMBL2092833 | — | — | 2 | 6.82 |
| CHEMBL220940 | THYMIDINE_TRIPHOSPHATE | — | 1 | 6.34 |
| CHEMBL2092835 | — | — | 2 | 6.30 |
| CHEMBL2092834 | — | — | 2 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483492 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2092833 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2092833 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL220940 | THYMIDINE_TRIPHOSPHATE | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL2092835 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL483492 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2092835 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2092834 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL2092834 | — | IC50 | = | 35000.0 | nM | 4.46 |