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Assay Detail

CHEMBL769333

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Human Protein kinase C delta
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Protein kinase C delta type (CHEMBL2996)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Protein kinase C inhibitory activities of balanol analogs bearing carboxylic acid replacements
Heerding JM, Lampe JW, Darges JW, Stamper ML
Bioorg Med Chem Lett (1995) 5 : 1839 -1842
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 6.91 9.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL52529 1 9.05
CHEMBL298872 1 7.70
CHEMBL294166 1 7.52
CHEMBL298159 1 7.05
CHEMBL53025 1 6.89
CHEMBL293722 1 6.52
CHEMBL299987 1 6.38
CHEMBL300658 1 5.70
CHEMBL55890 1 5.36
CHEMBL52869 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL52529 IC50 = 0.9 nM 9.05
CHEMBL298872 IC50 = 20.0 nM 7.70
CHEMBL294166 IC50 = 30.0 nM 7.52
CHEMBL298159 IC50 = 90.0 nM 7.05
CHEMBL53025 IC50 = 130.0 nM 6.89
CHEMBL293722 IC50 = 300.0 nM 6.52
CHEMBL299987 IC50 = 420.0 nM 6.38
CHEMBL300658 IC50 = 2000.0 nM 5.70
CHEMBL55890 IC50 = 4400.0 nM 5.36
CHEMBL52869 IC50 < 50.0 nM -