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Assay Detail

CHEMBL769352

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Binding
Inhibition of protein kinase C(1:1mixture of PKC alpha & beta) expressed in Sf9 insect cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type Sf9
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Novel protein kinase C inhibitors: alpha-terthiophene derivatives.
Kim DS, Ashendel CL, Zhou Q, Chang CT, Lee ES, Chang CJ.
Bioorg Med Chem Lett (1998) 8 : 2695 -2698
PubMed 9873605 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.94 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL388978 STAUROSPORINE 1 7.70
CHEMBL90598 1 6.52
CHEMBL314951 1 6.16
CHEMBL91933 1 6.16
CHEMBL330748 1 5.70
CHEMBL88617 1 5.70
CHEMBL90170 1 5.40
CHEMBL91518 1 5.16
CHEMBL90017 ALPHA-TERTHIENYL 1 5.00
CHEMBL422 TRIFLUOPERAZINE 4.0 1 -
CHEMBL314090 1 -
CHEMBL328441 2-THIOPHENENECARBOXALDEHYDE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL388978 STAUROSPORINE IC50 = 20.0 nM 7.70
CHEMBL90598 IC50 = 300.0 nM 6.52
CHEMBL314951 IC50 = 700.0 nM 6.16
CHEMBL91933 IC50 = 700.0 nM 6.16
CHEMBL330748 IC50 = 2000.0 nM 5.70
CHEMBL88617 IC50 = 2000.0 nM 5.70
CHEMBL90170 IC50 = 4000.0 nM 5.40
CHEMBL91518 IC50 = 7000.0 nM 5.16
CHEMBL90017 ALPHA-TERTHIENYL IC50 = 10000.0 nM 5.00
CHEMBL422 TRIFLUOPERAZINE IC50 = 500000.0 nM -
CHEMBL314090 IC50 = 700000.0 nM -
CHEMBL328441 2-THIOPHENENECARBOXALDEHYDE IC50 > 4000000.0 nM -