Assay Detail
Binding
CHEMBL769356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of HIV protease, using a peptide hydrolysis assay
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.12 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 9.47 |
| CHEMBL2062158 | — | — | 1 | 9.35 |
| CHEMBL69604 | — | — | 1 | 6.60 |
| CHEMBL2114201 | — | — | 1 | 5.33 |
| CHEMBL2114200 | — | — | 1 | 5.14 |
| CHEMBL2115206 | — | — | 2 | 5.07 |
| CHEMBL2115205 | — | — | 1 | 4.63 |
| CHEMBL431023 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL2062158 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL69604 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL2114201 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL2114200 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2115206 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL2115206 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL2115205 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL431023 | — | IC50 | = | 38000.0 | nM | 4.42 |