Assay Detail
Binding
CHEMBL769358
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Inhibition of HIV-1 protease in 10% fetal calf serum(FCS)
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Specific inhibition of HIV-1 protease by boronated porphyrins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.77 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350189 | — | — | 1 | 6.12 |
| CHEMBL408667 | — | — | 1 | 5.00 |
| CHEMBL430519 | 3-[18-(2-Carboxy-ethyl)-8,13-bis-(1,2-diacetoxy-ethyl)-3,7,12,17-tetramethyl-22,24-dihydro-porphin-2-yl]-propionic acid;Co complex | — | 1 | 4.60 |
| CHEMBL326831 | — | — | 2 | 4.60 |
| CHEMBL432254 | 3-[18-(2-Carboxy-ethyl)-8,13-bis-(1,2-diacetoxy-ethyl)-3,7,12,17-tetramethyl-22,24-dihydro-porphin-2-yl]-propionic acid;Mn complex | — | 1 | 4.19 |
| CHEMBL442513 | — | — | 1 | 4.12 |
| CHEMBL1325592 | PROTOPORPHYRIN | -1.0 | 1 | - |
| CHEMBL12659 | — | — | 1 | - |
| CHEMBL384612 | — | — | 1 | - |
| CHEMBL217693 | — | — | 1 | - |
| CHEMBL324788 | — | — | 1 | - |
| CHEMBL326715 | 3-[18-(2-Carboxy-ethyl)-8,13-bis-(1,2-diacetoxy-ethyl)-3,7,12,17-tetramethyl-22,24-dihydro-porphin-2-yl]-propionic acid;Cu complex | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350189 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL408667 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL430519 | 3-[18-(2-Carboxy-ethyl)-8,13-bis-(1,2-diacetoxy-ethyl)-3,7,12,17-tetramethyl-22,24-dihydro-porphin-2-yl]-propionic acid;Co complex | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL326831 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL432254 | 3-[18-(2-Carboxy-ethyl)-8,13-bis-(1,2-diacetoxy-ethyl)-3,7,12,17-tetramethyl-22,24-dihydro-porphin-2-yl]-propionic acid;Mn complex | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL442513 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL1325592 | PROTOPORPHYRIN | IC50 | > | 200000.0 | nM | - |
| CHEMBL12659 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL384612 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL217693 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL324788 | — | IC50 | < | 50000.0 | nM | - |
| CHEMBL326715 | 3-[18-(2-Carboxy-ethyl)-8,13-bis-(1,2-diacetoxy-ethyl)-3,7,12,17-tetramethyl-22,24-dihydro-porphin-2-yl]-propionic acid;Cu complex | IC50 | > | 70000.0 | nM | - |
| CHEMBL326831 | — | IC50 | > | 150000.0 | nM | - |