Assay Detail
Binding
CHEMBL769361
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Tested for inhibition of HIV protease
18
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-based design of HIV protease inhibitors: sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.35 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222559 | TIPRANAVIR | 4.0 | 1 | 7.52 |
| CHEMBL2112565 | — | — | 1 | 7.40 |
| CHEMBL2111769 | — | — | 1 | 6.96 |
| CHEMBL2092978 | — | — | 4 | 6.89 |
| CHEMBL2112563 | — | — | 1 | 6.85 |
| CHEMBL2111768 | — | — | 2 | 6.39 |
| CHEMBL2092977 | — | — | 1 | 6.31 |
| CHEMBL20846 | — | — | 1 | 6.00 |
| CHEMBL21281 | — | — | 1 | 5.96 |
| CHEMBL326566 | — | — | 1 | 5.92 |
| CHEMBL115743 | — | — | 1 | 5.80 |
| CHEMBL2062136 | — | — | 1 | 5.70 |
| CHEMBL22164 | — | — | 1 | 5.52 |
| CHEMBL2111770 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222559 | TIPRANAVIR | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2112565 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2111769 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2092978 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2112563 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2111768 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2092977 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL2092978 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL20846 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL21281 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL326566 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL115743 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2111768 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2062136 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL22164 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2092978 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2111770 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2092978 | — | IC50 | > | 1000.0 | nM | - |