Assay Detail
Binding
CHEMBL769364
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Inhibition of purified recombinant HIV-1 protease in a fluorogenic assay
78
Total Activities
78
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 8.01 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432806 | — | — | 1 | 9.00 |
| CHEMBL320126 | — | — | 1 | 8.92 |
| CHEMBL320322 | — | — | 1 | 8.85 |
| CHEMBL324916 | — | — | 1 | 8.82 |
| CHEMBL324747 | — | — | 1 | 8.80 |
| CHEMBL331363 | — | — | 1 | 8.80 |
| CHEMBL112930 | — | — | 1 | 8.80 |
| CHEMBL113575 | — | — | 1 | 8.78 |
| CHEMBL322804 | — | — | 1 | 8.77 |
| CHEMBL113626 | — | — | 1 | 8.66 |
| CHEMBL109221 | — | — | 1 | 8.64 |
| CHEMBL109371 | — | — | 1 | 8.52 |
| CHEMBL430891 | — | — | 1 | 8.52 |
| CHEMBL113627 | — | — | 1 | 8.40 |
| CHEMBL106486 | — | — | 1 | 8.32 |
| CHEMBL111957 | — | — | 1 | 8.28 |
| CHEMBL323955 | — | — | 1 | 8.28 |
| CHEMBL112578 | — | — | 1 | 8.24 |
| CHEMBL112186 | — | — | 1 | 8.17 |
| CHEMBL419580 | — | — | 1 | 8.15 |
| CHEMBL112546 | — | — | 1 | 8.15 |
| CHEMBL112846 | — | — | 1 | 8.12 |
| CHEMBL320321 | — | — | 1 | 8.11 |
| CHEMBL112412 | — | — | 1 | 8.05 |
| CHEMBL330915 | — | — | 1 | 8.05 |
| CHEMBL114192 | — | — | 1 | 8.00 |
| CHEMBL331829 | — | — | 1 | 7.92 |
| CHEMBL110865 | — | — | 1 | 7.89 |
| CHEMBL113264 | — | — | 1 | 7.89 |
| CHEMBL112569 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432806 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL320126 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL320322 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL324916 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL324747 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL331363 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL112930 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL113575 | — | IC50 | = | 1.66 | nM | 8.78 |
| CHEMBL322804 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL113626 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL109221 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL109371 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL430891 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL113627 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL106486 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL111957 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL323955 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL112578 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL112186 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL419580 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL112546 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL112846 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL320321 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL112412 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL330915 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL114192 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL331829 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL110865 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL113264 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL112569 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL333611 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL442010 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL109220 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL109699 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL322939 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL113268 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL411507 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL263534 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL325731 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL113554 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL322964 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL110603 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL326053 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL325847 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL320243 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL325673 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL331814 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL324746 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL109976 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL324163 | — | IC50 | < | 1.0 | nM | - |