Assay Detail
Binding
CHEMBL769369
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Inhibition of HIV-1 Protease.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.83 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99616 | — | — | 1 | 8.52 |
| CHEMBL98002 | — | — | 1 | 8.52 |
| CHEMBL317933 | — | — | 1 | 8.30 |
| CHEMBL322241 | TELINAVIR | 2.0 | 1 | 8.22 |
| CHEMBL100039 | — | — | 1 | 7.89 |
| CHEMBL98302 | — | — | 1 | 7.72 |
| CHEMBL329068 | — | — | 1 | 7.72 |
| CHEMBL98150 | — | — | 1 | 7.54 |
| CHEMBL99211 | — | — | 1 | 7.46 |
| CHEMBL430674 | — | — | 1 | 6.98 |
| CHEMBL100034 | — | — | 1 | 6.90 |
| CHEMBL317077 | — | — | 1 | 6.58 |
| CHEMBL98533 | — | — | 1 | 6.48 |
| CHEMBL99934 | — | — | 1 | 6.29 |
| CHEMBL99015 | — | — | 1 | 6.03 |
| CHEMBL48996 | — | — | 1 | 5.72 |
| CHEMBL607102 | — | — | 1 | 5.29 |
| CHEMBL607101 | — | — | 1 | 5.19 |
| CHEMBL99317 | — | — | 1 | 5.00 |
| CHEMBL99268 | — | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99616 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL98002 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL317933 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL322241 | TELINAVIR | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL100039 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL98302 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL329068 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL98150 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL99211 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL430674 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL100034 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL317077 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL98533 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL99934 | — | IC50 | = | 518.0 | nM | 6.29 |
| CHEMBL99015 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL48996 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL607102 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL607101 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL99317 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL99268 | — | IC50 | = | 54000.0 | nM | 4.27 |