Assay Detail
Binding
CHEMBL769370
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Concentration needed to inhibit HIV- protease activity by 50%.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
New series of potent, orally bioavailable, non-peptidic cyclic sulfones as HIV-1 protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.25 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL326764 | — | — | 1 | 9.52 |
| CHEMBL323814 | — | — | 1 | 9.22 |
| CHEMBL324071 | — | — | 1 | 9.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL326764 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL323814 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL324071 | — | IC50 | = | 1.0 | nM | 9.00 |