Assay Detail
Binding
CHEMBL769376
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Concentration required for in vitro inhibitory activity against HIV-1 protease
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
D-amino acids as novel P2/P3 ligands for inhibitors of HIV-1 protease
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.44 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277985 | — | — | 1 | 9.52 |
| CHEMBL275237 | — | — | 1 | 9.52 |
| CHEMBL418527 | — | — | 1 | 7.38 |
| CHEMBL276704 | — | — | 1 | 7.35 |
| CHEMBL31510 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277985 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL275237 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL418527 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL276704 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL31510 | — | IC50 | > | 1000.0 | nM | - |