Assay Detail
Binding
CHEMBL769406
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV-1 protease
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Application of the three-dimensional structures of protein target molecules in structure-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.89 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48565 | — | — | 1 | 9.66 |
| CHEMBL289846 | — | — | 1 | 9.66 |
| CHEMBL300968 | — | — | 1 | 9.42 |
| CHEMBL307193 | — | — | 1 | 8.52 |
| CHEMBL3143979 | — | — | 1 | 8.00 |
| CHEMBL2311105 | — | — | 1 | 7.92 |
| CHEMBL275554 | — | — | 1 | 7.92 |
| CHEMBL9726 | — | — | 1 | 7.40 |
| CHEMBL9618 | — | — | 1 | 6.55 |
| CHEMBL3351009 | — | — | 1 | 6.23 |
| CHEMBL9409 | — | — | 1 | 5.52 |
| CHEMBL9417 | — | — | 1 | - |
| CHEMBL9735 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48565 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL289846 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL300968 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL307193 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3143979 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2311105 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL275554 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL9726 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL9618 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3351009 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL9409 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL9417 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL9735 | — | IC50 | > | 10000.0 | nM | - |