Assay Detail
Binding
CHEMBL769440
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity of the Compound was tested against HIV protease enzyme.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Intriguing structure-activity relations underlie the potent inhibition of HIV protease by norstatine-based peptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.88 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3085518 | — | — | 1 | 9.24 |
| CHEMBL334985 | — | — | 1 | 8.89 |
| CHEMBL335391 | — | — | 1 | 8.72 |
| CHEMBL3349662 | — | — | 1 | 8.37 |
| CHEMBL3349847 | — | — | 1 | 8.13 |
| CHEMBL3085515 | — | — | 1 | 7.70 |
| CHEMBL3085514 | — | — | 1 | 7.58 |
| CHEMBL3085513 | — | — | 1 | 7.57 |
| CHEMBL132945 | — | — | 1 | 7.08 |
| CHEMBL335676 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3085518 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL334985 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL335391 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3349662 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3349847 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL3085515 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3085514 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3085513 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL132945 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL335676 | — | IC50 | = | 3100.0 | nM | 5.51 |