Assay Detail
Functional
CHEMBL769481
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro growth inhibition against Plasmodium falciparum
102
Total Activities
102
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 102 | 4.95 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.92 |
| CHEMBL54004 | — | — | 1 | 6.08 |
| CHEMBL416301 | — | — | 1 | 5.97 |
| CHEMBL55810 | — | — | 1 | 5.67 |
| CHEMBL56073 | — | — | 1 | 5.54 |
| CHEMBL55264 | — | — | 1 | 5.36 |
| CHEMBL56255 | (PENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 5.32 |
| CHEMBL298852 | — | — | 1 | 5.28 |
| CHEMBL299988 | — | — | 1 | 5.26 |
| CHEMBL56556 | — | — | 1 | 5.11 |
| CHEMBL54714 | — | — | 1 | 4.97 |
| CHEMBL52251 | (OCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.88 |
| CHEMBL294192 | — | — | 1 | 4.77 |
| CHEMBL301572 | MORPHOLINOMETHYLENEDIPHOSPHONIC ACID | — | 1 | 4.74 |
| CHEMBL54537 | — | — | 1 | 4.64 |
| CHEMBL298547 | — | — | 1 | 4.57 |
| CHEMBL55837 | — | — | 1 | 4.54 |
| CHEMBL56028 | — | — | 1 | 4.50 |
| CHEMBL53982 | — | — | 1 | 4.50 |
| CHEMBL301244 | — | — | 1 | 4.47 |
| CHEMBL54888 | — | — | 1 | 4.33 |
| CHEMBL291727 | — | — | 1 | 4.30 |
| CHEMBL299491 | — | — | 1 | 4.25 |
| CHEMBL56254 | (HEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.25 |
| CHEMBL55988 | — | — | 1 | 4.23 |
| CHEMBL293479 | — | — | 1 | 4.12 |
| CHEMBL54344 | (DIETHYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.04 |
| CHEMBL55221 | CYCLOHEXYL(HYDROXY)METHYLENEDIPHOSPHONIC ACID | — | 1 | - |
| CHEMBL55779 | (DICYCLOHEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | - |
| CHEMBL301857 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL54004 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL416301 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL55810 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL56073 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL55264 | — | IC50 | = | 4340.0 | nM | 5.36 |
| CHEMBL56255 | (PENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL298852 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL299988 | — | IC50 | = | 5530.0 | nM | 5.26 |
| CHEMBL56556 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL54714 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL52251 | (OCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL294192 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL301572 | MORPHOLINOMETHYLENEDIPHOSPHONIC ACID | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL54537 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL298547 | — | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL55837 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL56028 | — | IC50 | = | 31300.0 | nM | 4.50 |
| CHEMBL53982 | — | IC50 | = | 31400.0 | nM | 4.50 |
| CHEMBL301244 | — | IC50 | = | 33550.0 | nM | 4.47 |
| CHEMBL54888 | — | IC50 | = | 46300.0 | nM | 4.33 |
| CHEMBL291727 | — | IC50 | = | 50400.0 | nM | 4.30 |
| CHEMBL299491 | — | IC50 | = | 56700.0 | nM | 4.25 |
| CHEMBL56254 | (HEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 56500.0 | nM | 4.25 |
| CHEMBL55988 | — | IC50 | = | 59100.0 | nM | 4.23 |
| CHEMBL293479 | — | IC50 | = | 76600.0 | nM | 4.12 |
| CHEMBL54344 | (DIETHYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 90100.0 | nM | 4.04 |
| CHEMBL52761 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL298771 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL52306 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL55572 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL292224 | (CYCLOPROPYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | > | 200000.0 | nM | - |
| CHEMBL293116 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL430963 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL294478 | (ISOBUTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | > | 200000.0 | nM | - |
| CHEMBL412889 | (CYCLOOCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | > | 200000.0 | nM | - |
| CHEMBL55557 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL54747 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL52137 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL870 | ALENDRONIC ACID | IC50 | > | 200000.0 | nM | - |
| CHEMBL834 | PAMIDRONIC ACID | IC50 | > | 200000.0 | nM | - |
| CHEMBL55886 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL417194 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL55358 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL56704 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL433833 | — | IC50 | = | 103000.0 | nM | - |
| CHEMBL434978 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL299717 | (PROPYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | > | 200000.0 | nM | - |
| CHEMBL52620 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL299443 | (4-HYDROXYPHENETHYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | > | 200000.0 | nM | - |