Assay Detail
Binding
CHEMBL769501
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Inhibition of HIV-2 protease in 5%DMSO
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 2 pol protein (CHEMBL5074) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 2 |
Publication
Specific inhibition of HIV-1 protease by boronated porphyrins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.52 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350189 | — | — | 1 | 7.52 |
| CHEMBL326831 | — | — | 2 | 6.16 |
| CHEMBL324788 | — | — | 1 | 6.00 |
| CHEMBL430519 | 3-[18-(2-Carboxy-ethyl)-8,13-bis-(1,2-diacetoxy-ethyl)-3,7,12,17-tetramethyl-22,24-dihydro-porphin-2-yl]-propionic acid;Co complex | — | 1 | 5.82 |
| CHEMBL408667 | — | — | 1 | 5.81 |
| CHEMBL326715 | 3-[18-(2-Carboxy-ethyl)-8,13-bis-(1,2-diacetoxy-ethyl)-3,7,12,17-tetramethyl-22,24-dihydro-porphin-2-yl]-propionic acid;Cu complex | — | 1 | 5.66 |
| CHEMBL268410 | — | — | 1 | 4.89 |
| CHEMBL442513 | — | — | 1 | 4.75 |
| CHEMBL384612 | — | — | 1 | 4.64 |
| CHEMBL217693 | — | — | 1 | 4.52 |
| CHEMBL1325592 | PROTOPORPHYRIN | -1.0 | 1 | - |
| CHEMBL12659 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350189 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL326831 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL324788 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL430519 | 3-[18-(2-Carboxy-ethyl)-8,13-bis-(1,2-diacetoxy-ethyl)-3,7,12,17-tetramethyl-22,24-dihydro-porphin-2-yl]-propionic acid;Co complex | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL408667 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL326715 | 3-[18-(2-Carboxy-ethyl)-8,13-bis-(1,2-diacetoxy-ethyl)-3,7,12,17-tetramethyl-22,24-dihydro-porphin-2-yl]-propionic acid;Cu complex | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL326831 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL268410 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL442513 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL384612 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL217693 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1325592 | PROTOPORPHYRIN | IC50 | = | 500000.0 | nM | - |
| CHEMBL12659 | — | IC50 | = | 480000.0 | nM | - |