Assay Detail
Binding
CHEMBL769552
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Inhibitory activity against purified rat liver phosphodiesterase 4
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Improvement of therapeutic index of phosphodiesterase type IV inhibitors as anti-Asthmatics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.83 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 9.51 |
| CHEMBL76635 | — | — | 1 | 9.24 |
| CHEMBL432348 | — | — | 1 | 9.22 |
| CHEMBL76382 | — | — | 1 | 8.85 |
| CHEMBL77999 | — | — | 1 | 8.81 |
| CHEMBL78238 | — | — | 1 | 8.80 |
| CHEMBL77788 | — | — | 1 | 8.76 |
| CHEMBL76257 | — | — | 1 | 8.43 |
| CHEMBL77745 | — | — | 1 | 8.35 |
| CHEMBL431962 | — | — | 1 | 8.31 |
| CHEMBL77177 | — | — | 1 | - |
| CHEMBL306320 | — | — | 1 | - |
| CHEMBL77358 | — | — | 1 | - |
| CHEMBL75684 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63 | ROLIPRAM | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL76635 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL432348 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL76382 | — | IC50 | = | 1.42 | nM | 8.85 |
| CHEMBL77999 | — | IC50 | = | 1.56 | nM | 8.81 |
| CHEMBL78238 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL77788 | — | IC50 | = | 1.75 | nM | 8.76 |
| CHEMBL76257 | — | IC50 | = | 3.72 | nM | 8.43 |
| CHEMBL77745 | — | IC50 | = | 4.51 | nM | 8.35 |
| CHEMBL431962 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL77177 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL306320 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL77358 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL75684 | — | IC50 | > | 10.0 | nM | - |