Assay Detail
Binding
CHEMBL769643
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf9 cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Subcellular | Microsomes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 2,3-diarylthiophenes as selective cox-2 inhibitors. part II: Replacing the heterocycle
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.18 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | — | 1 | 8.15 |
| CHEMBL328837 | — | — | 1 | 7.52 |
| CHEMBL274893 | SC-57666 | — | 1 | 6.80 |
| CHEMBL274990 | SC-58125 | — | 1 | 6.70 |
| CHEMBL274473 | — | — | 1 | 6.51 |
| CHEMBL16850 | — | — | 1 | 6.51 |
| CHEMBL319306 | — | — | 1 | 6.33 |
| CHEMBL355263 | — | — | 1 | 5.92 |
| CHEMBL366807 | — | — | 1 | 5.68 |
| CHEMBL171646 | — | — | 1 | 5.29 |
| CHEMBL367778 | — | — | 1 | 5.23 |
| CHEMBL368409 | — | — | 1 | 5.19 |
| CHEMBL355771 | — | — | 1 | 4.52 |
| CHEMBL355781 | — | — | 1 | - |
| CHEMBL174009 | — | — | 1 | - |
| CHEMBL170591 | — | — | 1 | - |
| CHEMBL173961 | — | — | 1 | - |
| CHEMBL43165 | — | — | 1 | - |
| CHEMBL366886 | — | — | 1 | - |
| CHEMBL97935 | — | — | 1 | - |
| CHEMBL171360 | — | — | 1 | - |
| CHEMBL443819 | — | — | 1 | - |
| CHEMBL367885 | — | — | 1 | - |
| CHEMBL170639 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL328837 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL274893 | SC-57666 | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL274990 | SC-58125 | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL274473 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL16850 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL319306 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL355263 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL366807 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL171646 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL367778 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL368409 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL355771 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL355781 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL174009 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL170591 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL173961 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL43165 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL366886 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL97935 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL171360 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL443819 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL367885 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL170639 | — | IC50 | > | 30000.0 | nM | - |