Assay Detail
Binding
CHEMBL769644
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Inhibitory activity was evaluated against human Prostaglandin G/H synthase 2 was determined
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of a new cyclooxygenase-2 lead compound through 3-D database searching and combinatorial chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.82 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56367 | NIMESULIDE | 4.0 | 1 | 7.82 |
| CHEMBL359113 | — | — | 1 | 5.89 |
| CHEMBL149032 | — | — | 1 | 5.40 |
| CHEMBL151658 | — | — | 1 | 5.30 |
| CHEMBL147074 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56367 | NIMESULIDE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL359113 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL149032 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL151658 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL147074 | — | IC50 | = | 21000.0 | nM | 4.68 |