Assay Detail
Binding
CHEMBL769653
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Tested for inhibition against Prostaglandin G/H synthase 2
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally active COX-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.80 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127674 | — | — | 1 | 8.52 |
| CHEMBL340573 | — | — | 1 | 8.52 |
| CHEMBL108201 | — | — | 1 | 8.30 |
| CHEMBL320784 | — | — | 1 | 8.15 |
| CHEMBL7162 | NS-398 | — | 1 | 8.00 |
| CHEMBL89578 | — | — | 1 | 7.82 |
| CHEMBL274893 | SC-57666 | — | 1 | 7.58 |
| CHEMBL322045 | — | — | 1 | 7.29 |
| CHEMBL108975 | — | — | 1 | 7.28 |
| CHEMBL111045 | — | — | 1 | 7.17 |
| CHEMBL321182 | — | — | 1 | 7.12 |
| CHEMBL274990 | SC-58125 | — | 1 | 7.05 |
| CHEMBL111039 | — | — | 1 | 6.66 |
| CHEMBL109030 | — | — | 1 | 6.06 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 5.92 |
| CHEMBL340458 | — | — | 1 | 5.65 |
| CHEMBL109578 | — | — | 1 | 5.50 |
| CHEMBL109486 | — | — | 1 | 5.18 |
| CHEMBL129215 | — | — | 1 | 4.19 |
| CHEMBL338105 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127674 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL340573 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL108201 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL320784 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL7162 | NS-398 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL89578 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL274893 | SC-57666 | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL322045 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL108975 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL111045 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL321182 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL274990 | SC-58125 | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL111039 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL109030 | — | IC50 | = | 865.0 | nM | 6.06 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL340458 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL109578 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL109486 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL129215 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL338105 | — | IC50 | = | 77900.0 | nM | 4.11 |