Assay Detail
Binding
CHEMBL769655
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Tested in vitro for inhibition against Prostaglandin G/H synthase 2 in human blood (95% confidence limits)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole derivatives: a new series of potent and selective COX-2 inhibitors in which a sulfonyl group is not a structural requisite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 10.01 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143776 | — | — | 1 | 10.10 |
| CHEMBL140167 | — | — | 1 | 9.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143776 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL140167 | — | IC50 | = | 0.12 | nM | 9.92 |