Assay Detail
Binding
CHEMBL769656
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Tested in vitro for the ability to inhibit Prostaglandin G/H synthase 2 in chinese hamster ovary (CHO) cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.60 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | — | 1 | 8.70 |
| CHEMBL156482 | — | — | 1 | 8.52 |
| CHEMBL421826 | — | — | 1 | 8.52 |
| CHEMBL157714 | — | — | 1 | 8.22 |
| CHEMBL158316 | — | — | 1 | 8.00 |
| CHEMBL348115 | — | — | 1 | 7.96 |
| CHEMBL155927 | — | — | 1 | 7.89 |
| CHEMBL156399 | — | — | 1 | 7.82 |
| CHEMBL348087 | — | — | 1 | 7.70 |
| CHEMBL157820 | — | — | 1 | 7.66 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.58 |
| CHEMBL346094 | — | — | 1 | 7.50 |
| CHEMBL156493 | — | — | 1 | 7.44 |
| CHEMBL348645 | — | — | 1 | 7.32 |
| CHEMBL155980 | — | — | 1 | 7.10 |
| CHEMBL348104 | — | — | 1 | 6.82 |
| CHEMBL157623 | — | — | 1 | 6.64 |
| CHEMBL347378 | — | — | 1 | 6.58 |
| CHEMBL346288 | — | — | 1 | 6.35 |
| CHEMBL157358 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL156482 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL421826 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL157714 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL158316 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL348115 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL155927 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL156399 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL348087 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL157820 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL346094 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL156493 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL348645 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL155980 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL348104 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL157623 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL347378 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL346288 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL157358 | — | IC50 | > | 50000.0 | nM | - |