Assay Detail
Binding
CHEMBL769657
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was evaluated for its inhibitory activity against Prostaglandin G/H synthase 2 using osteosarcomes cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.10 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7162 | NS-398 | — | 1 | 9.00 |
| CHEMBL423638 | — | — | 1 | 7.30 |
| CHEMBL166156 | — | — | 1 | 5.00 |
| CHEMBL165946 | — | — | 1 | - |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | - |
| CHEMBL164393 | — | — | 1 | - |
| CHEMBL349518 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7162 | NS-398 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL423638 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL166156 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL165946 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL93 | ZILEUTON | IC50 | > | 10000.0 | nM | - |
| CHEMBL164393 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL349518 | — | IC50 | > | 10000.0 | nM | - |