Assay Detail
Functional
CHEMBL769667
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antimalarial activity against Plasmodium falciparum Vl/S with quadruple DHFR mutant (N51I/C59R/S108N/I164L)
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL1939) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum K1 |
Publication
Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.90 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22137 | — | — | 1 | 5.52 |
| CHEMBL279948 | — | — | 1 | 5.51 |
| CHEMBL120123 | — | — | 1 | 5.32 |
| CHEMBL22138 | — | — | 1 | 5.09 |
| CHEMBL22139 | — | — | 1 | 5.01 |
| CHEMBL118602 | — | — | 1 | 4.95 |
| CHEMBL274031 | — | — | 1 | 4.89 |
| CHEMBL416373 | — | — | 1 | 4.80 |
| CHEMBL21395 | — | — | 1 | 4.78 |
| CHEMBL22901 | — | — | 1 | 4.71 |
| CHEMBL416376 | — | — | 1 | 4.67 |
| CHEMBL56146 | — | — | 1 | 4.67 |
| CHEMBL22811 | — | — | 1 | 4.58 |
| CHEMBL119224 | — | — | 1 | 4.53 |
| CHEMBL22146 | — | — | 1 | 4.42 |
| CHEMBL419055 | — | — | 1 | - |
| CHEMBL325533 | — | — | 1 | - |
| CHEMBL291931 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22137 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL279948 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL120123 | — | IC50 | = | 4820.0 | nM | 5.32 |
| CHEMBL22138 | — | IC50 | = | 8130.0 | nM | 5.09 |
| CHEMBL22139 | — | IC50 | = | 9750.0 | nM | 5.01 |
| CHEMBL118602 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL274031 | — | IC50 | = | 12750.0 | nM | 4.89 |
| CHEMBL416373 | — | IC50 | = | 15910.0 | nM | 4.80 |
| CHEMBL21395 | — | IC50 | = | 16470.0 | nM | 4.78 |
| CHEMBL22901 | — | IC50 | = | 19450.0 | nM | 4.71 |
| CHEMBL416376 | — | IC50 | = | 21120.0 | nM | 4.67 |
| CHEMBL56146 | — | IC50 | = | 21490.0 | nM | 4.67 |
| CHEMBL22811 | — | IC50 | = | 26080.0 | nM | 4.58 |
| CHEMBL119224 | — | IC50 | = | 29610.0 | nM | 4.53 |
| CHEMBL22146 | — | IC50 | = | 38020.0 | nM | 4.42 |
| CHEMBL419055 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL325533 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL291931 | — | IC50 | > | 50000.0 | nM | - |