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Assay Detail

CHEMBL769670

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Functional
In vitro antimalarial activity relative to artemisinin against Plasmodium falciparum W-2 (Indochina)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and antimalarial activity of some 9-substituted artemisinin derivatives.
Acton N, Karle JM, Miller RE.
J Med Chem (1993) 36 : 2552 -2557
PubMed 8355254 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.19 5.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL85857 1 5.64
CHEMBL84611 1 5.47
CHEMBL315942 1 5.43
CHEMBL315412 1 5.38
CHEMBL85012 1 5.12
CHEMBL526138 ARTEMISITENE 1 5.11
CHEMBL314692 1 5.10
CHEMBL83633 1 5.07
CHEMBL315323 1 4.36
CHEMBL83177 1 -
CHEMBL82863 1 -
CHEMBL269671 ARTEMISININ 3.0 1 -
CHEMBL315907 1 -
CHEMBL86254 1 -
CHEMBL314927 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL85857 IC50 = 2300.0 nM 5.64
CHEMBL84611 IC50 = 3400.0 nM 5.47
CHEMBL315942 IC50 = 3700.0 nM 5.43
CHEMBL315412 IC50 = 4200.0 nM 5.38
CHEMBL85012 IC50 = 7600.0 nM 5.12
CHEMBL526138 ARTEMISITENE IC50 = 7800.0 nM 5.11
CHEMBL314692 IC50 = 8000.0 nM 5.10
CHEMBL83633 IC50 = 8600.0 nM 5.07
CHEMBL315323 IC50 = 44000.0 nM 4.36
CHEMBL83177 IC50 = 290000.0 nM -
CHEMBL82863 IC50 = 123000.0 nM -
CHEMBL269671 ARTEMISININ IC50 = 0.001 ug.mL-1 -
CHEMBL315907 IC50 = 429000.0 nM -
CHEMBL86254 IC50 = 242000.0 nM -
CHEMBL314927 IC50 = 408000.0 nM -