Assay Detail
Binding
CHEMBL769674
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of phosphodiesterase 4
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
New substituted triaza-benzo[cd]azulen-9-ones as promising phosphodiesterase-4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.21 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112366 | — | — | 1 | 6.57 |
| CHEMBL111925 | — | — | 1 | 5.96 |
| CHEMBL112996 | — | — | 2 | 5.37 |
| CHEMBL418848 | — | — | 1 | 5.36 |
| CHEMBL2111730 | — | — | 1 | 5.21 |
| CHEMBL113368 | — | — | 1 | 4.64 |
| CHEMBL109754 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112366 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL111925 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL112996 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL418848 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL2111730 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL113368 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL109754 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL112996 | — | IC50 | = | 73000.0 | nM | 4.14 |