Assay Detail
Binding
CHEMBL769675
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Inhibition of Phosphodiesterase 4
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Biarylcarboxylic acids and -amides: inhibition of phosphodiesterase type IV versus [3H]rolipram binding activity and their relationship to emetic behavior in the ferret.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.29 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281781 | — | — | 1 | 7.09 |
| CHEMBL278386 | — | — | 1 | 6.96 |
| CHEMBL21305 | — | — | 1 | 6.89 |
| CHEMBL282934 | — | — | 1 | 6.89 |
| CHEMBL21839 | — | — | 1 | 6.85 |
| CHEMBL280185 | — | — | 1 | 6.80 |
| CHEMBL422219 | — | — | 1 | 6.52 |
| CHEMBL22461 | — | — | 1 | 6.39 |
| CHEMBL21964 | — | — | 1 | 6.28 |
| CHEMBL22898 | — | — | 1 | 6.17 |
| CHEMBL280729 | — | — | 1 | 5.85 |
| CHEMBL21463 | — | — | 1 | 5.79 |
| CHEMBL22189 | — | — | 1 | 5.71 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.46 |
| CHEMBL279896 | — | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281781 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL278386 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL21305 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL282934 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL21839 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL280185 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL422219 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL22461 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL21964 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL22898 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL280729 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL21463 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL22189 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL279896 | — | IC50 | = | 20300.0 | nM | 4.69 |