Assay Detail
Binding
CHEMBL769678
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Inhibitory activity on human eosinophil phosphodiesterase 4.
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as novel inhibitors of human eosinophil phosphodiesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.22 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | 2.0 | 1 | 8.05 |
| CHEMBL307678 | — | — | 1 | 7.47 |
| CHEMBL309803 | — | — | 1 | 7.41 |
| CHEMBL76066 | — | — | 1 | 7.32 |
| CHEMBL74597 | — | — | 1 | 7.20 |
| CHEMBL75247 | — | — | 1 | 6.82 |
| CHEMBL307286 | — | — | 1 | 6.80 |
| CHEMBL308784 | — | — | 1 | 6.80 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 6.77 |
| CHEMBL75722 | — | — | 1 | 6.57 |
| CHEMBL305806 | — | — | 1 | 6.38 |
| CHEMBL75819 | — | — | 1 | 6.36 |
| CHEMBL76065 | — | — | 1 | 6.34 |
| CHEMBL406941 | — | — | 1 | 6.31 |
| CHEMBL310509 | — | — | 1 | 6.18 |
| CHEMBL32442 | CDP840 | — | 1 | 6.17 |
| CHEMBL74251 | — | — | 1 | 6.05 |
| CHEMBL72688 | — | — | 1 | 5.97 |
| CHEMBL307144 | — | — | 1 | 5.79 |
| CHEMBL73894 | — | — | 1 | 5.79 |
| CHEMBL308180 | — | — | 1 | 5.65 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.48 |
| CHEMBL74774 | — | — | 1 | 5.22 |
| CHEMBL74361 | — | — | 1 | 4.80 |
| CHEMBL307511 | — | — | 1 | 4.07 |
| CHEMBL306335 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL307678 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL309803 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL76066 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL74597 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL75247 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL307286 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL308784 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL75722 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL305806 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL75819 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL76065 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL406941 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL310509 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL32442 | CDP840 | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL74251 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL72688 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL307144 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL73894 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL308180 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL74774 | — | IC50 | = | 6040.0 | nM | 5.22 |
| CHEMBL74361 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL307511 | — | IC50 | = | 84700.0 | nM | 4.07 |
| CHEMBL306335 | — | IC50 | = | 84900.0 | nM | 4.07 |