Assay Detail
Binding
CHEMBL769679
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Inhibition of Phosphodiesterase 4 from human U937 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and profile of SCH351591, a novel PDE4 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.93 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42387 | — | — | 1 | 7.46 |
| CHEMBL40200 | — | — | 1 | 7.29 |
| CHEMBL250546 | SCH-351591 | — | 1 | 7.22 |
| CHEMBL607242 | — | — | 1 | 7.16 |
| CHEMBL288195 | — | — | 1 | 6.92 |
| CHEMBL607241 | — | — | 1 | 6.82 |
| CHEMBL607240 | — | — | 1 | 6.62 |
| CHEMBL42479 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42387 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL40200 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL250546 | SCH-351591 | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL607242 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL288195 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL607241 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL607240 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL42479 | — | IC50 | = | 1120.0 | nM | 5.95 |