Assay Detail
Binding
CHEMBL769680
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Inhibition of [3H]rolipram binding in human peripheral blood mononuclear cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis of 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridine-6-yl)-benzoic acid: a potent and selective phosphodiesterase type 4D inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.54 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74078 | — | — | 1 | 9.22 |
| CHEMBL77826 | — | — | 1 | 9.00 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74078 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL77826 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 40.0 | nM | 7.40 |