Assay Detail
Functional
CHEMBL769865
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect on IgE/Fcepsilon RI triggered rat basophil cell (RBL-2H3) degranulation assessed by measuring the amount of 5-HT release
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Low affinity immunoglobulin epsilon Fc receptor (CHEMBL2940) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potent small molecule inhibitors of spleen tyrosine kinase (Syk).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 5.78 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318079 | — | — | 1 | 7.00 |
| CHEMBL104519 | — | — | 1 | 6.96 |
| CHEMBL104279 | — | — | 1 | 6.50 |
| CHEMBL104333 | — | — | 1 | 5.85 |
| CHEMBL104691 | — | — | 1 | 5.71 |
| CHEMBL104813 | — | — | 1 | 5.46 |
| CHEMBL322152 | — | — | 1 | 5.25 |
| CHEMBL321976 | — | — | 1 | 5.20 |
| CHEMBL104651 | — | — | 1 | 5.16 |
| CHEMBL105438 | — | — | 1 | 4.68 |
| CHEMBL431645 | — | — | 1 | - |
| CHEMBL316756 | — | — | 1 | - |
| CHEMBL108258 | — | — | 1 | - |
| CHEMBL107061 | — | — | 1 | - |
| CHEMBL106226 | — | — | 1 | - |
| CHEMBL322153 | — | — | 1 | - |
| CHEMBL105427 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318079 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL104519 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL104279 | — | EC50 | = | 313.0 | nM | 6.50 |
| CHEMBL104333 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL104691 | — | EC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL104813 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL322152 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL321976 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL104651 | — | EC50 | = | 6960.0 | nM | 5.16 |
| CHEMBL105438 | — | EC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL431645 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL316756 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL108258 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL107061 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL106226 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL322153 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL105427 | — | EC50 | > | 10000.0 | nM | - |