Assay Detail
Binding
CHEMBL770263
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Inhibition of cAMP-dependent kinase PKA(Protein kinase A) catalytic subunit at 100 uM
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cAMP-dependent protein kinase catalytic subunit alpha (CHEMBL3390) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Substituted 2-(aminomethyl)piperidines: a novel class of selective protein kinase C inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.29 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.57 |
| CHEMBL67166 | SPHINGOSINE | — | 1 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL67166 | SPHINGOSINE | IC50 | = | 98.0 | nM | 7.01 |