Assay Detail
Binding
CHEMBL770286
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Displacement of [3H-20]-phorbol-12-13-dibutyrate from protein kinase C (alpha, beta, gamma) of mouse brain
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Conformationally constrained analogues of diacylglycerol. 9.1 the effect of side-chain orientation on the protein kinase C (PK-C) binding affinity of -lactones
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.02 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422215 | — | — | 1 | 6.70 |
| CHEMBL13306 | — | — | 1 | 6.22 |
| CHEMBL276429 | — | — | 1 | 5.60 |
| CHEMBL311296 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422215 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL13306 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL276429 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL311296 | — | Ki | = | 2800.0 | nM | 5.55 |