Assay Detail
Binding
CHEMBL770288
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Inhibition of [3H]phorbol-12,13-dibutyrate binding to mouse brain protein kinase C
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Conformationally constrained analogues of diacylglycerol. 6. Changes in PK-C binding affinity for 3-O-acyl-2-deoxy-L-ribonolactones bearing different acyl chains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.41 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL331699 | — | — | 1 | 5.92 |
| CHEMBL120742 | — | — | 1 | 5.88 |
| CHEMBL122771 | — | — | 1 | 5.62 |
| CHEMBL121951 | — | — | 1 | 5.61 |
| CHEMBL276429 | — | — | 1 | 5.60 |
| CHEMBL121791 | — | — | 1 | 5.50 |
| CHEMBL118552 | — | — | 1 | 5.39 |
| CHEMBL13044 | — | — | 1 | 5.28 |
| CHEMBL120974 | — | — | 1 | 5.06 |
| CHEMBL333244 | — | — | 1 | 5.05 |
| CHEMBL120196 | — | — | 1 | 4.63 |
| CHEMBL327155 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL331699 | — | Ki | = | 1210.0 | nM | 5.92 |
| CHEMBL120742 | — | Ki | = | 1330.0 | nM | 5.88 |
| CHEMBL122771 | — | Ki | = | 2390.0 | nM | 5.62 |
| CHEMBL121951 | — | Ki | = | 2450.0 | nM | 5.61 |
| CHEMBL276429 | — | Ki | = | 2530.0 | nM | 5.60 |
| CHEMBL121791 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL118552 | — | Ki | = | 4060.0 | nM | 5.39 |
| CHEMBL13044 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL120974 | — | Ki | = | 8690.0 | nM | 5.06 |
| CHEMBL333244 | — | Ki | = | 8900.0 | nM | 5.05 |
| CHEMBL120196 | — | Ki | = | 23470.0 | nM | 4.63 |
| CHEMBL327155 | — | Ki | = | 187600.0 | nM | - |