Assay Detail
Binding
CHEMBL770291
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Inhibition of [3H]PDBu binding to murine brain PKC (protein kinase C)
12
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Cyclohexane diester analogues of phorbol ester as potential activators of protein kinase C.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.65 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279115 | PHORBOL MYRISTATE ACETATE | 2.0 | 1 | 8.00 |
| CHEMBL55267 | — | — | 1 | 5.30 |
| CHEMBL58131 | — | — | 1 | - |
| CHEMBL294299 | — | — | 2 | - |
| CHEMBL58102 | — | — | 2 | - |
| CHEMBL58780 | — | — | 2 | - |
| CHEMBL292754 | — | — | 1 | - |
| CHEMBL292960 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279115 | PHORBOL MYRISTATE ACETATE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL55267 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL58131 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL294299 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL58102 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL58780 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL58102 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL294299 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL292754 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL58780 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL292960 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL292960 | — | IC50 | > | 1000000.0 | nM | - |