Assay Detail
Functional
CHEMBL770465
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antagonist activity (ANG II like) expressed as percent activity relative to ANG II in rabbit aorta strip assay.
25
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Aorta |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
An investigation of angiotensin II agonist and antagonist analogues with 5,5-dimethylthiazolidine-4-carboxylic acid and other constrained amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 25 | 8.31 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2370349 | — | — | 1 | 9.70 |
| CHEMBL328167 | — | — | 1 | 9.60 |
| CHEMBL404594 | — | — | 1 | 9.10 |
| CHEMBL2370367 | — | — | 1 | 9.00 |
| CHEMBL2364552 | — | — | 1 | 9.00 |
| CHEMBL2370346 | — | — | 1 | 9.00 |
| CHEMBL321952 | — | — | 1 | 8.90 |
| CHEMBL317439 | — | — | 1 | 8.70 |
| CHEMBL408595 | — | — | 1 | 8.70 |
| CHEMBL312754 | — | — | 2 | 8.61 |
| CHEMBL322627 | — | — | 1 | 8.40 |
| CHEMBL263278 | — | — | 1 | 8.30 |
| CHEMBL317253 | — | — | 1 | 8.30 |
| CHEMBL263360 | — | — | 1 | 8.25 |
| CHEMBL318091 | — | — | 1 | 8.00 |
| CHEMBL385919 | — | — | 1 | 7.64 |
| CHEMBL2370356 | — | — | 1 | 7.50 |
| CHEMBL2311163 | — | — | 1 | 7.50 |
| CHEMBL103336 | — | — | 1 | 7.50 |
| CHEMBL406385 | — | — | 1 | 7.17 |
| CHEMBL427769 | — | — | 1 | 7.00 |
| CHEMBL2370348 | — | — | 1 | 6.70 |
| CHEMBL267751 | — | — | 1 | - |
| CHEMBL2370371 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2370349 | — | Kd | = | 0.1995 | nM | 9.70 |
| CHEMBL328167 | — | Kd | = | 0.2512 | nM | 9.60 |
| CHEMBL404594 | — | Kd | = | 0.7943 | nM | 9.10 |
| CHEMBL2370367 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL2364552 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL2370346 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL321952 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL317439 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL408595 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL312754 | — | Kd | = | 2.455 | nM | 8.61 |
| CHEMBL312754 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL322627 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL317253 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL263278 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL263360 | — | Kd | = | 5.623 | nM | 8.25 |
| CHEMBL318091 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL385919 | — | Kd | = | 22.91 | nM | 7.64 |
| CHEMBL2370356 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL2311163 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL103336 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL406385 | — | Kd | = | 67.61 | nM | 7.17 |
| CHEMBL427769 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL2370348 | — | Kd | = | 199.53 | nM | 6.70 |
| CHEMBL267751 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL2370371 | — | Kd | > | 1000.0 | nM | - |