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Assay Detail

CHEMBL770924

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory effect on PAF induced platelets aggregation in rabbit
18
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Platelet-activating factor receptor (CHEMBL250)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Enantiodifferentiation of dihydropyridine PAF antagonists
Cooper K, Jonathan Fray M, John Parry M, Richardson K, Steele J
Bioorg Med Chem Lett (1995) 5 : 3085 -3090
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 7.82 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL29067 3 8.70
CHEMBL104967 1 8.64
CHEMBL104290 1 8.52
CHEMBL322029 1 8.19
CHEMBL104843 1 8.12
CHEMBL317911 1 8.10
CHEMBL318391 1 8.10
CHEMBL104978 1 7.96
CHEMBL319839 1 7.82
CHEMBL440149 1 7.77
CHEMBL53019 1 7.68
CHEMBL105908 1 7.66
CHEMBL320241 1 7.31
CHEMBL432393 1 7.22
CHEMBL105029 1 6.74
CHEMBL104620 1 6.38

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL29067 IC50 = 2.0 nM 8.70
CHEMBL104967 IC50 = 2.3 nM 8.64
CHEMBL104290 IC50 = 3.0 nM 8.52
CHEMBL29067 IC50 = 4.9 nM 8.31
CHEMBL322029 IC50 = 6.5 nM 8.19
CHEMBL104843 IC50 = 7.5 nM 8.12
CHEMBL317911 IC50 = 8.0 nM 8.10
CHEMBL318391 IC50 = 8.0 nM 8.10
CHEMBL104978 IC50 = 11.0 nM 7.96
CHEMBL319839 IC50 = 15.0 nM 7.82
CHEMBL440149 IC50 = 17.0 nM 7.77
CHEMBL53019 IC50 = 21.0 nM 7.68
CHEMBL105908 IC50 = 22.0 nM 7.66
CHEMBL29067 IC50 = 31.3 nM 7.50
CHEMBL320241 IC50 = 49.0 nM 7.31
CHEMBL432393 IC50 = 60.0 nM 7.22
CHEMBL105029 IC50 = 183.0 nM 6.74
CHEMBL104620 IC50 = 415.0 nM 6.38